Recruiting

How a hormone affects teenage girls with and without high androgen levels

Plain-English translation of NCT00929006 on ClinicalTrials.gov ↗ · Source last updated August 2025 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This study is testing how affects hormone patterns in teenage girls going through puberty. Researchers want to understand whether this natural hormone works differently in girls who have high levels of androgens (male-like hormones) compared to girls with normal hormone levels. The medication will be given during two overnight stays at a research hospital, several months apart.

Some teenage girls develop high androgen levels, which can cause unwanted hair growth and irregular periods. Researchers want to understand how progesterone affects these hormone patterns in girls with this condition, so they can eventually develop better treatments.

Do you qualify?

You likely qualify if…

you are a teenage girl in mid-to-late puberty (breast development stage 3 or higher, but no more than 2 years after your first period)
you have either normal testosterone levels or high testosterone levels with or without excess facial/body hair
you are in general good health (you may be overweight or have high androgen levels)
you are willing and able to use reliable non-hormonal birth control during the study
you and your parent or guardian are willing to give permission and understand the study

You likely don't qualify if…

you are pregnant, trying to become pregnant, or currently breastfeeding
you have a history of rapid hair growth, voice deepening, or other signs of severe androgen excess
you have thyroid disease that is not well controlled, or high prolactin levels
you have signs of eating disorders, excessive exercise, or severe stress affecting your period
you have low blood counts (anemia) or other blood cell abnormalities

What participation looks like

You will visit the research hospital for two separate overnight stays, at least 2 months apart. During each 18-hour stay, you will receive either the medication or a placebo (fake pill) four times by mouth, and doctors will draw small blood samples every 10 minutes through an IV catheter to measure hormone levels while you are awake and while you sleep. One overnight stay will involve the actual medication, and the other will be the placebo—you won't know which is which.

AI-generated summary from trial data · Jun 3, 2026 · Not medical advice

Trial locations(1 site)

United States

University of Virginia, Charlottesville, Virginia