Plain-English translation of NCT01143480 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Asthma research guide →This research study is looking at how specific genes you inherit influence the way your immune system reacts to bacterial toxins. Researchers will take a small blood sample from you, grow immune cells from that sample in the lab, and expose them to bacterial toxins to see how they respond based on your genetics. The goal is to understand why some people's immune systems react differently to infections.
Scientists believe that differences in our genes may explain why some people are more prone to inflammatory diseases like asthma, heart disease, and metabolic problems. By studying how genetic variations affect immune cell behavior, researchers hope to eventually develop better ways to predict and treat these conditions.
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Your involvement would be a single visit lasting about 1 to 1.5 hours. During this visit, you'll have approximately 200 milliliters (about 7 ounces) of blood drawn. Researchers will then take your blood cells to the lab, isolate immune cells called macrophages, and expose them to bacterial toxins to observe how they respond based on your genetic makeup. If you're part of a specific genetic study group, you may also provide a urine sample.
AI-generated summary from trial data · Sep 19, 2026 · Not medical advice
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