Plain-English translation of NCT01192048 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are trying to understand why some people are born with heart defects by studying the genes of people with congenital heart disease and their relatives. By analyzing blood samples using advanced genetic sequencing technology, the team hopes to identify which specific genes cause these heart conditions. This knowledge could one day help doctors better predict, diagnose, and treat heart defects in newborns.
Congenital heart disease is the most common birth defect, but doctors still don't fully understand what causes it. By finding the genes responsible, researchers could help future families understand their risk and potentially develop better treatments.
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If you join this study, you will be asked to give a blood sample, which takes only a few minutes. Researchers will use advanced genetic sequencing to analyze your DNA and look for genes linked to heart disease. You may be asked to share basic medical information, and family members may also be invited to participate.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Enrollment target
~5,000 participants
Started
December 2009
Primary completion
December 2030
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Katherine M Spayde, MS, CGC
Nationwide Children's Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.