Plain-English translation of NCT01269853 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing a new way to deliver the medication directly to your brain tumor. Instead of receiving the medication through an IV in your arm (the standard way), this treatment uses a special catheter placed in an artery to deliver the medication right to the tumor site. The goal is to see if getting the medication directly to the brain is safer and more effective than the usual approach.
Standard brain tumor treatment often doesn't work as well as doctors hope because medications given through an IV don't always reach the brain effectively due to a natural barrier that protects the brain. This trial is designed to find out if delivering the medication directly to the tumor site can work better and help patients live longer.
You likely qualify if…
You likely don't qualify if…
You would come to the hospital for a procedure where doctors place a small catheter (thin tube) into an artery and guide it to your brain tumor. Before the medication is delivered, you'll receive an injection to temporarily open the barrier around your brain so the medication can reach the tumor. The medication is then delivered directly through the catheter. You may also receive the standard IV treatment as well, depending on which study group you're assigned to. The trial is designed to test whether this direct delivery method works better than the standard approach.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States