Plain-English translation of NCT01409109 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Schizophrenia research guide →This is a research registry that invites 1,000 people—some with schizophrenia or schizoaffective disorder and some without mental illness—to participate in a series of brain imaging studies. Researchers will use magnetic resonance imaging (MRI) scans to look at how brains function during memory tasks and at rest, along with blood work and cognitive testing, to build a database that helps scientists understand the biological differences in how people with these conditions process information.
Schizophrenia and schizoaffective disorder affect how the brain processes memories, thoughts, and perception, but researchers still don't fully understand the brain-level causes. This study aims to create a large database of brain imaging and behavioral data that can help identify biological markers—measurable brain changes—that may improve diagnosis and treatment in the future.
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You will visit the research center for clinical interviews, blood work, and cognitive task training on a computer. Once you're trained on the tasks, you'll have the option to undergo MRI and fMRI brain scans—specialized imaging that takes pictures of your brain while you perform memory tasks or rest quietly. During the scans, you'll see images on a screen and press buttons to respond. The study does not change your current medications or treatment, and participation involves no experimental drugs or invasive procedures.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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