Plain-English translation of NCT01752738 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand how chronic kidney disease affects the way your intestines absorb certain chemicals made by gut bacteria. These chemicals, called indoxyl sulfate and p-cresyl sulfate, can build up in the blood when kidneys aren't working well and may contribute to heart disease and kidney damage. This study will examine colon tissue samples from kidney disease patients to learn how these chemicals are processed.
When kidneys don't work properly, harmful chemicals from gut bacteria build up in the body and may speed up kidney disease and heart problems. Doctors don't yet understand exactly how these chemicals move through the intestines, so this research aims to uncover new ways to treat and slow kidney disease.
You will undergo a colonoscopy as you normally would for medical reasons. During that procedure, doctors will take small tissue samples from your colon — this happens as part of the routine exam and causes no extra discomfort. The tissue samples will then be studied in the laboratory to understand how your intestines handle these gut chemicals. Your participation ends after the colonoscopy.
AI-generated summary from trial data · Jun 24, 2026 · Not medical advice
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