Long-term safety and effectiveness of psoriasis treatments in everyday practice

PsoBest is a German registry that tracks patients with moderate to severe psoriasis or psoriatic arthritis who are starting treatment with systemic medications—either conventional drugs like methotrexate or biological treatments like adalimumab, etanercept, infliximab, and ustekinumab. The study has been running since 2008 and aims to understand how well these treatments work in real patients over the long term, not just in controlled clinical trials.

While doctors know these medications work well in short- and medium-term studies, we don't have much information about how they perform over years of actual patient care, what side effects people experience, and which patients respond best to which treatments. This registry fills that gap by collecting real-world data to guide better treatment decisions.