Plain-English translation of NCT01875588 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is a 20-year research study designed to understand how HIV affects the brain and thinking abilities, even when HIV is well-controlled with medications. Researchers will follow about 500 people with HIV and 250 people without HIV, using memory tests, brain imaging, and blood work to track changes over time and learn more about how the brain responds to HIV infection.
Although modern HIV medications have made the most severe forms of brain-related complications much less common, many people with HIV still experience thinking and memory problems. Researchers don't yet fully understand why this happens or how to prevent it, so this study aims to fill that gap by carefully tracking brain health over many years.
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You would visit the research center yearly for up to 10 years for screening and ongoing assessments. Each visit includes memory and thinking tests, blood and urine samples, and brain MRI scans. Some participants may be offered additional optional tests like a lumbar puncture (spinal tap) or PET/CT imaging. The study is designed to follow you over time to see how your brain health changes and to help researchers better understand how HIV affects thinking and memory.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
United States