Plain-English translation of NCT02288676 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Ovarian Neoplasms research guide →This trial is developing and testing a new genetic test designed to detect ovarian and endometrial cancer early by looking for cancer-related DNA changes in samples taken from women's cervix, uterus, or blood. Researchers are comparing samples from women who have confirmed or suspected cancer with samples from women undergoing surgery for benign (non-cancerous) conditions to train the test to tell the difference between cancer and non-cancerous disease.
Ovarian and endometrial cancers are often diagnosed at advanced stages when they are harder to treat and cure rates have stalled for decades. This trial exists because current methods like imaging and blood tests are not good at catching these cancers early, especially the aggressive forms that spread quickly while still undetectable. The new genetic test could potentially find cancer at an earlier, more treatable stage.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will provide biological samples (such as cervical, uterine, or blood samples) before your scheduled surgery. Researchers will analyze these samples to look for cancer-related genetic changes and test whether the new genetic test can accurately identify cancer versus benign disease. Your participation involves providing samples at the time of your surgery, with no additional visits required beyond your standard surgical care.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
Canada
Sponsor
McGill University
Collaborators
McGill University Health Centre/Research Institute of the McGill University Health Centre
Enrollment target
~1,200 participants
Started
January 2014
Primary completion
October 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Sex
Female only
Last updated on clinicaltrials.gov in June 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Dr. Lucy Gilbert, MD,MSc,FRCOG
McGill Genome Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.