Plain-English translation of NCT02411773 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
People with chronic kidney disease often struggle with exercise and have poor physical fitness, which increases their heart disease risk. This trial tests whether a combination of regular exercise training and —a common supplement—can help improve blood flow to muscles during activity and make exercise easier. Researchers want to understand why kidney disease patients have trouble with exercise and whether this treatment approach could help.
Patients with chronic kidney disease experience abnormal blood pressure responses during exercise and have trouble getting enough blood flow to their muscles when active. This treatment approach may help by improving how blood vessels relax and reducing excessive tightening during physical activity, which could allow patients to exercise more comfortably and reduce their heart disease risk.
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You would visit a research center three times per week for 6 to 12 weeks. During each visit, you would either do moderate exercise on a stationary bike for 20 to 45 minutes or do stretching and toning exercises. Before each session, you would take either pills or a placebo (dummy) pill. Researchers would measure your blood pressure, heart response, and muscle blood flow during and after exercise to see whether the treatment helps your body respond better to physical activity.
AI-generated summary from trial data · Jun 26, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
Emory University
Enrollment target
~110 participants
Started
June 2015
Primary completion
June 2027
Age range
18 Years – 75 Years
Last updated on clinicaltrials.gov in May 2026.
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Central contact
Dana DaCosta
Emory University
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