Plain-English translation of NCT02434393 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is trying to understand why older adults with depression often experience problems with thinking and memory that get worse over time. Researchers will use brain imaging (MRI and PET scans) and blood tests to look for biological markers and changes in the brain that might explain the connection between depression and memory loss. The study will follow participants for 30 months to track these changes.
Doctors have noticed that older people with depression seem to develop memory and thinking problems faster than those without depression, but we don't fully understand why. This study aims to identify the brain changes and biological factors that cause this acceleration, which could eventually lead to better treatments or prevention strategies.
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You will have two main study visits spaced several months apart over 30 months. At each visit, you'll complete a brain MRI scan and specialized PET scans (which show how amyloid and tau proteins are distributed in your brain), provide blood samples for genetic testing and biomarker analysis, and complete cognitive tests and questionnaires about your mood and memory. Between visits, researchers may also collect health information and track any changes in your depression symptoms or thinking abilities.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
United States