Recruiting

Understanding different asthma patterns in children through long-term monitoring

Plain-English translation of NCT02496468 on ClinicalTrials.gov ↗ · Source last updated August 2024 · Translation generated June 2026 · How we translate trials

Read our Asthma research guide →

What is this trial?

This is a long-term research study that follows children with asthma or recurring wheezing episodes over time. Researchers want to understand why some children's symptoms go away on their own while others develop lifelong asthma. By collecting information about your child's symptoms, genes, environment, and responses to treatment, the study aims to help doctors predict asthma outcomes and develop more personalized treatment plans in the future.

Doctors know that about one-quarter of children wheeze at some point, but they don't fully understand why some children recover while others develop persistent asthma. Understanding these differences could help doctors catch and treat asthma earlier, before it becomes a chronic lifelong condition.

Do you qualify?

You likely qualify if…

you have a child between 6 months and 18 years old
your child has experienced recurrent wheezing (more than 2 episodes in the past year for younger children, or doctor-diagnosed asthma for children 6 years and older)
your child was born at full-term (37 weeks or later)
you and your child (if older than 8 years) can speak and understand German
you provide informed permission for your child to participate

You likely don't qualify if…

your child has a known lung disease from birth or shortly after birth
your child has airway malformations or structural problems
your child has other serious lung or heart conditions such as cystic fibrosis or interstitial lung disease
your child has a fever of 38.5°C or higher in the two weeks before enrollment
your child required prolonged oxygen therapy or mechanical ventilation after birth

What participation looks like

If your child is newly diagnosed with asthma or wheezing, you'll complete an initial visit with detailed health information, breathing tests, and blood samples for genetic and molecular analysis. You'll then return for regular follow-up visits using the same measurements, and additional visits if your child has an asthma flare-up. If your child is already being treated for asthma, you'll follow a similar schedule of monitoring visits. Healthy children (control group) participate in just the initial visit. All visits follow standardized procedures to ensure consistent, high-quality data collection across all participating sites.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Trial locations(5 sites)

Germany

University Children's Hospital Cologne, Department of Paediatric Allergology and Pneumology, Cologne

Medizinische Hochschule Hannover, Biomedical Research in Endstage and Obstructive Lung Disease, Hanover

Universitaetsklinikum Schleswig-Holstein, Klinik für Kinder- und Jugendmedizin, Airway Research Center North, Lübeck

Klinik für Kinder- und Jugendmedizin, Universitaetsklinikum Giessen und Marburg GmbH, Universities of Giessen and Marburg Lung Center, Marburg

Klinikum der Universitaet Muenchen, Comprehensive Pulmonary Center Munich, Munich