Plain-English translation of NCT02535221 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This study is comparing two different ways to treat early breast cancer in women who are still having periods. Some participants will receive hormone-based treatment using goserelin, tamoxifen, and aromatase inhibitors, while others will receive traditional chemotherapy drugs. The goal is to see if the hormone-based approach works just as well as chemotherapy at shrinking tumors before surgery.
Younger women with hormone-sensitive breast cancer have traditionally been treated with chemotherapy, but chemotherapy can cause significant side effects. This trial is exploring whether hormone-based treatment might be equally effective with potentially fewer side effects, giving patients another option.
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If you join this trial, you will be randomly assigned to receive either hormone therapy or chemotherapy before your breast cancer surgery. The hormone therapy group will receive injections and oral medications over 4 to 5 months, while the chemotherapy group will receive intravenous infusions over the same period. You will have regular ultrasound scans to monitor how well the treatment is working before you proceed to surgery.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
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