Plain-English translation of NCT02620852 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The WISDOM Study is testing whether breast cancer screening should be tailored to each woman's personal risk rather than using a one-size-fits-all approach of annual mammograms for everyone. Women in this trial will either receive standard annual mammograms or personalized screening recommendations based on their family history, personal health information, and genetic testing results.
Doctors and researchers have been debating the best approach to breast cancer screening for years. Some say annual mammograms catch more cancers early, while others worry that too many women get false alarms and unnecessary treatment. This trial aims to find out whether a personalized approach—screening only as often as each woman's individual risk requires—could work just as well while reducing worry and unnecessary testing.
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You will complete a health questionnaire and be randomly assigned to either standard annual mammograms or personalized risk-based screening. If assigned to personalized screening, you will provide a saliva sample for genetic testing to identify your individual breast cancer risk. Based on your results, you will receive customized screening recommendations that may include a starting age, stopping age, and how often you should be screened. Throughout the study, you will follow your assigned screening plan and may be asked to complete follow-up surveys.
AI-generated summary from trial data · Aug 28, 2026 · Not medical advice
United States
Sex
Female only
Last updated on clinicaltrials.gov in November 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Allison Fiscalini, MPH
University of California, San Francisco
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.