Plain-English translation of NCT02621021 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new approach to melanoma treatment that uses your own immune cells. Doctors will remove immune cells from your tumor, grow more of them in the laboratory, and then give them back to you along with high-dose IL-2 (a medication that boosts immune function). Some participants will also receive , a checkpoint inhibitor that helps your immune system fight cancer more effectively.
Melanoma that has spread is very difficult to treat, and many patients don't respond well to current medications. This trial is trying to see if combining this treatment with a checkpoint inhibitor can help more patients achieve better responses and longer survival.
You likely qualify if…
You likely don't qualify if…
First, doctors will surgically remove a small piece of your tumor to extract immune cells. These cells will be sent to the laboratory where they are grown and multiplied over several weeks. While that happens, you will receive chemotherapy to prepare your body. Then you will receive an infusion of your grown immune cells followed by high-dose IL-2 injections. Some participants will also receive either before or after the cell infusion. You will need to stay in the hospital during the intensive treatment phase and return for follow-up visits to monitor how well the treatment is working.
AI-generated summary from trial data · Aug 31, 2026 · Not medical advice
United States