Taking a psychiatric medication once daily instead of twice daily

This is a pilot study testing whether clozapine can be taken once daily instead of twice daily in people with schizophrenia or schizoaffective disorder. Currently, the medication instructions say to take it multiple times a day, but many doctors and patients already give it once daily because it's more convenient and may reduce side effects like daytime drowsiness. This study wants to know if once-daily dosing works just as well as the traditional twice-daily approach.

While other similar psychiatric medications have been proven to work well on a once-daily schedule, no one has formally studied whether this medication can safely be switched to once-daily dosing. Many doctors are already doing this in real practice, but we need proper research to confirm it's safe and effective.