Plain-English translation of NCT02641769 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This clinical trial is testing a new procedure called intra-testicular transplantation of autologous stem cells. Researchers will take stem cells from a patient's own bone marrow, purify them in the laboratory, and then transplant them directly into the testicles. The goal is to help restore the testicles' ability to produce sperm in men who have been diagnosed with non-obstructive azoospermia—a condition where abnormal testicular function prevents sperm production.
Currently, men with non-obstructive azoospermia have very few treatment options beyond using surgically retrieved sperm for in vitro fertilization. This trial exists to explore whether could improve or restore the testicles' natural sperm-producing ability, offering a new hope for men who want to father biological children naturally.
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If you enroll in this trial, you will undergo bone marrow harvesting to collect your own stem cells, which will then be processed in a laboratory. You will then have a surgical procedure to transplant these purified stem cells directly into your testicles. The trial is recruiting 600 participants and is currently in Phase 1 and Phase 2, meaning researchers are still evaluating the safety and effectiveness of this approach. Your doctor will monitor your progress over time to see whether the transplant helps restore your sperm production.
AI-generated summary from trial data · Jul 2, 2026 · Not medical advice
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