Plain-English translation of NCT02844751 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing a treatment called autologous cell therapy — which uses cells collected from your own body fat — to see if it can reduce pain and inflammation in knees damaged by arthritis. Researchers will inject these cells directly into your knee, along with platelet-rich plasma (a concentrate made from your own blood), and track whether your pain improves over six months. The trial will start with 50 patients and then expand to 4,000 if the early results look promising.
Knee arthritis can be very painful and limit your ability to move, but current treatments don't work for everyone and some people end up needing surgery. This trial is exploring whether using your body's own cells might offer a new way to reduce pain and inflammation without major surgery.
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You will receive an injection of cells collected from your own fat, plus additional injections of platelet-rich plasma on a schedule determined by your doctor—either more frequent early injections or spread out over a couple of months. You'll be asked to return for follow-up visits, imaging scans (MRI) of your knee, blood tests, and questionnaires about your pain and quality of life over the next 6 months. Researchers will track whether your pain decreases, your mobility improves, and whether you need fewer pain medications or can delay knee replacement surgery.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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