Plain-English translation of NCT02861781 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This research study collects small tissue samples during weight loss surgery (bariatric surgery) to understand why severe obesity leads to type 2 diabetes in some people but not others. Researchers will examine these tissues in detail and also check your blood samples 3 and 12 months after surgery to see how things change. The goal is to find new clues about the biological processes that cause diabetes so better treatments can be developed.
Type 2 diabetes and severe obesity often go together, but doctors don't fully understand why some obese people develop diabetes while others don't. This study aims to find the biological differences that explain this, which could eventually lead to better ways to prevent or treat the disease.
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You will participate in this study at the time of your scheduled weight loss surgery. During the surgery, the surgical team will collect small tissue samples from areas important for metabolism (such as fat tissue, muscle, and liver). After surgery, you'll have blood tests at 3 months and 12 months after your operation to track changes in your metabolism. The tissue and blood samples will be analyzed for various biological markers and genetic information to help researchers understand the link between obesity and diabetes.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
France