Plain-English translation of NCT02915198 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This study is testing whether metformin—a medication commonly used to prevent diabetes—can help reduce heart attacks, strokes, and related deaths in veterans who have both prediabetes and existing heart or blood vessel disease. About 7,400 people will participate, and each person will randomly receive either the medication or a placebo (a pill that looks identical but has no active ingredient). Everyone in the study will also receive guidance on healthy lifestyle changes.
Many veterans have prediabetes and existing heart disease, which puts them at high risk for heart attacks and strokes. Doctors want to know if this medication, which is safe and inexpensive, can help prevent these serious events in this high-risk group.
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If you join, you'll be randomly assigned to take either the medication or a matching placebo pill once daily, with the dose gradually increased over time up to 4 tablets daily based on how well you tolerate it. You'll have regular study visits to check your health, have blood tests, and discuss any side effects or concerns. Throughout the study, you'll also receive counseling on heart-healthy lifestyle choices like diet and exercise. The trial is ongoing, so your commitment would span months to potentially several years.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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