Plain-English translation of NCT02919280 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →This is an observational study — meaning researchers watch and track your health over time rather than testing a new medication. The Dallas 2K study will follow 2,500 people with depression or bipolar disorder for 10 years to understand why some people respond well to treatment while others struggle, and what factors influence recovery. By collecting information about your life, medical history, habits, and biology, researchers hope to develop better ways to predict which treatments will work best for each person.
Right now, doctors often have to try different antidepressants before finding one that works for a patient — a process that can take months or years. This study exists to understand the personal, lifestyle, and biological factors that predict treatment success, so doctors can eventually match people with the right medication faster and help more patients achieve lasting recovery.
You likely qualify if…
You likely don't qualify if…
You would visit the research clinic multiple times over 10 years for assessments and to provide samples. At appointments, you'll complete interviews and questionnaires about your mood and health, provide blood, saliva, and urine samples, and may have brain imaging (MRI) and brain activity recordings (EEG). You may also be asked to use a phone app or wristband to track your health continuously. The study is flexible — researchers understand that life happens, and missing some appointments won't disqualify you.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States