Plain-English translation of NCT02919280 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →Dallas 2K is a 10-year study designed to help researchers understand why some people recover well from depression while others struggle. The study will follow 2,500 participants with depression or bipolar disorder to identify the personal, lifestyle, biological, and brain-related factors that predict how well someone will respond to depression treatment and what their long-term outlook will be.
Depression affects millions of people, but we don't fully understand why the same antidepressant medication works well for some people and not for others. By studying a large, diverse group of people over many years, researchers hope to develop better ways to predict who will improve with treatment and design more personalized approaches to depression care.
You will visit the study clinic multiple times over the 10-year period for appointments where you'll answer questions about your mood, medical history, and daily habits. You'll also provide samples (blood, saliva, urine, stool), have brain scans, and wear monitoring devices. Some appointments may include an EEG to measure brain activity. You can optionally use a phone app or wristband to share information continuously. The study is observational, meaning no new medication or treatment is being tested—researchers are simply tracking your depression journey and collecting information to identify patterns in recovery.
AI-generated summary from trial data · Sep 16, 2026 · Not medical advice
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