Plain-English translation of NCT02954939 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Lupus Nephritis research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial tests two different treatment strategies for lupus nephritis—a serious condition where lupus damages the kidneys. One approach uses mycophenolate mofetil (a medication that quiets an overactive immune system), while the other uses cyclophosphamide followed by a different maintenance medication. Researchers will track how each treatment affects your immune cells and whether it helps prevent the disease from flaring up again.
Lupus nephritis is hard to treat and patients often experience relapses even after initial treatment. This study aims to understand which approach better controls the immune system and reduces the risk of the disease returning, so doctors can offer patients the best possible care.
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You will receive one of two medication regimens for 6 months, then continue with a maintenance treatment afterward. You'll visit the clinic at multiple time points over 48 weeks (about one year) for blood tests to measure your immune cell counts and other markers. The research team will track how your immune system responds to the treatment and whether your disease remains stable or relapses.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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