Plain-English translation of NCT02964858 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether patients with diffuse large B-cell lymphoma (a type of blood cancer) can be treated with a lower dose of radiation after completing chemotherapy. Currently, doctors use a standard radiation dose, but this trial wants to find out if giving less radiation over a shorter time works just as well while potentially causing fewer side effects.
Radiation therapy can damage healthy cells and cause long-term side effects, so doctors want to know if they can achieve the same cure rates with a smaller, safer dose—especially important for younger patients who may live for many decades after treatment.
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After you finish your 4–6 cycles of chemotherapy, you will be randomly assigned to receive either the standard radiation dose (45 Gray over 5 weeks) or the lower test dose (36 Gray over 4 weeks). Both use the same type of focused radiation aimed at the cancer sites. You will attend daily radiation appointments during your treatment period, and the trial team will track your response and any side effects over time.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
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