Plain-English translation of NCT03014687 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
After surgery to remove a pituitary tumor through the nose, doctors sometimes prescribe oral antibiotics to help the nasal passages heal. This trial is testing whether those oral antibiotics actually make a difference in how well the nose recovers after surgery. You would receive either real antibiotics or a placebo (a dummy pill) for 7 days after your surgery, and researchers would track your healing over time.
Pituitary surgery naturally disrupts the nasal passages and sinuses, which can cause crusting, infections, and stuffy nose for weeks afterward. While doctors routinely prescribe antibiotics hoping to prevent these problems, recent research in similar surgeries suggests the medication may not actually help—and antibiotics can have side effects. This study aims to find out whether this medication is truly beneficial or if standard care alone is enough.
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You would have your pituitary tumor surgery as planned. Starting the morning after surgery, you would take either oral antibiotics or a placebo pill twice daily for 7 days—you won't know which one you're taking. You would complete short surveys about your nasal symptoms and quality of life at several time points over the following weeks, and your doctor would examine your nasal passages during follow-up visits to assess how well the area is healing.
AI-generated summary from trial data · Jul 21, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Collaborators
Thomas Jefferson University, The Cleveland Clinic
Enrollment target
~116 participants
Started
July 2017
Primary completion
January 2019
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 84 Years
Last updated on clinicaltrials.gov in August 2018.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Heidi Jahnke, RN, MSN
Barrow Brain and Spine
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.