Plain-English translation of NCT03065335 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is investigating how works in the brains of people with treatment-resistant depression—a form of depression that hasn't improved with standard antidepressants. Researchers will give you through an IV and use brain imaging (like MRI) and other tests to see how the medication affects your brain activity. The study will also test whether receiving multiple doses of over time can help maintain improvement in your symptoms.
Standard antidepressants don't work for everyone, and some people struggle with depression for years without relief. This medication has shown promise in helping people quickly, but doctors don't yet fully understand how it works in the brain or which patients are most likely to benefit from it. This research could help identify who will respond well to this treatment.
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Your participation includes several phases over weeks. First, you'll have screening visits and may need to stop or reduce other medications with a medication-free period. Then you'll receive either or saline (salt water) infusions through an IV—some infusions will happen inside a brain scanner or with brain-monitoring equipment. In later phases, you may receive multiple infusions at different doses to see if repeated doses help maintain improvement. Throughout, you'll complete brain scans, blood tests, questionnaires about your mood, and other measurements to track how you're responding.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
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