Testing a new injectable medication versus insulin for hard-to-control diabetes with weight gain

This trial is testing whether liraglutide, an injectable medication that helps your body use insulin better and may support weight loss, works better than adding another insulin (glargine) for people with type 2 diabetes who are overweight and not getting good control with their current medications. You would receive either liraglutide plus fast-acting insulin shots at meals, or glargine plus fast-acting insulin shots at meals, and researchers will track how well each approach controls your blood sugar over 24 weeks.

Many people with type 2 diabetes who are overweight end up needing more and more insulin over time, which can lead to further weight gain and dangerous low blood sugar episodes. Researchers want to find out whether this medication—which works differently than insulin and may help with weight loss—could be a better choice than simply adding more basal insulin for patients in this situation.