Stem cell transplant from a half-matched relative for severe sickle cell disease

This trial is testing a stem cell transplant procedure for people with severe sickle cell disease who have complications like strokes, frequent pain crises, or organ damage. You would receive stem cells from a half-matched family member (a parent, sibling, or other relative who shares about half of your immune system markers). Before the transplant, you'll receive low-dose radiation and chemotherapy medications to prepare your body to accept the new cells, along with immunosuppressive drugs afterward to help prevent rejection.

Most sickle cell patients who need a transplant don't have a perfectly matched sibling donor available. This trial is testing whether using a half-matched family member as a donor—combined with special conditioning and rejection-prevention medications—can make transplants possible and successful for more patients.