Plain-English translation of NCT03136146 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination of chemotherapy drugs—including , , , liposomal vincristine, , and —for patients whose acute lymphoblastic leukemia or lymphoblastic lymphoma has come back or stopped responding to prior treatment. The study aims to see if this medication combination can help patients achieve remission and how safe and effective it is. Researchers will also track how long remissions last and how patients survive over time.
Patients whose blood cancers return or don't respond to standard treatment have very limited options. This trial exists to test whether a new combination of existing chemotherapy drugs can work better for these difficult-to-treat cases and help more patients achieve remission.
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You would receive chemotherapy drugs through an IV (intravenous line) and by injection over several days during an induction phase, then continue with consolidation therapy in cycles lasting about 28 days. The treatment involves five to six different medications given on specific days throughout each cycle, along with supportive medications to help manage side effects. You would likely need multiple hospital or clinic visits over several months as you complete the initial treatment and then up to five consolidation cycles, with regular blood tests and check-ins to monitor your response and watch for side effects.
AI-generated summary from trial data · Aug 20, 2026 · Not medical advice
United States