Plain-English translation of NCT03140865 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is a research study that builds a long-term database and sample repository to help scientists across the United States better understand Alzheimer's disease and memory problems. Researchers will collect your medical history, thinking and memory assessments, brain scans, and (optionally) blood or spinal fluid samples. This shared information will help multiple research teams work together more efficiently to find new ways to detect memory problems early and develop better treatments.
Memory problems and Alzheimer's disease are serious conditions affecting many older adults, but we still don't have reliable early warning signs or proven treatments. By collecting standardized information and samples from many people—some with normal memory, some with mild problems, and some with Alzheimer's—researchers can study the patterns and changes that happen over time. This shared database will help the scientific community move faster toward discovering new tools for early detection and innovative treatments.
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You will visit the research clinic at baseline and then once per year for 5 years. At certain visits, you'll have memory and thinking tests, a brain MRI scan, and a glucose tolerance test (drinking a sugary drink to check your blood sugar). If you choose the optional biomarker substudy, you'll also have a lumbar puncture (spinal tap) to collect spinal fluid. A study partner—a family member or close friend—needs to attend at least your first visit or be available by phone to answer questions about your memory and daily activities. All your information and samples will be stored and shared with other Alzheimer's research centers across the country.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
United States