Plain-English translation of NCT03161652 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a medication called levosulpiride to see if it can help prevent and treat vision problems caused by diabetes. Specifically, researchers want to know if levosulpiride can help protect the retina (the light-sensing part of your eye) and reduce swelling in the macula (the central part of your vision) in people with diabetic eye disease. The medication works by increasing levels of a natural hormone called prolactin, which early research suggests may protect the eyes.
Diabetic eye disease is a major cause of blindness in working-age adults, and current treatments—like lasers or frequent eye injections—don't always prevent vision loss or come with risks. This trial exists to explore whether this medication could offer a safer, gentler way to protect vision by working on a completely different part of the disease process.
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You will be randomly assigned to take either the study medication or a placebo (sugar pill) by mouth. Depending on your type of diabetic eye disease, you may also be receiving other standard treatments like eye injections or surgery—the study medication would be added to your regular care. You will have regular appointments where doctors will examine your eyes, check your vision, and run blood tests to measure how well the treatment is working and to watch for any side effects.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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