Plain-English translation of NCT03208868 on ClinicalTrials.gov ↗ ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a leucine-enriched essential amino acid mixture to see if it can help rebuild muscle mass in people with cirrhosis. Cirrhosis causes patients to lose muscle tissue, which makes their condition more serious and riskier for transplant surgery if they need it. The researchers believe this amino acid supplement may work by restarting the body's natural muscle-building process.
Muscle loss is one of the most common and serious complications of cirrhosis, but there is currently no proven treatment to prevent or reverse it. This trial exists to test whether the medication can safely and effectively rebuild muscle in cirrhosis patients.
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You will be randomly assigned to receive either the leucine-enriched amino acid supplement or a comparison amino acid supplement for 3 months. During the study, you'll have clinic visits where researchers will take blood samples, perform muscle biopsies (small tissue samples), take body measurements, and do imaging scans to track changes in your muscle mass. The study involves tracer studies using special labeled amino acids to measure how your muscles are building protein.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
United States