Plain-English translation of NCT03213002 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing whether combining two oral medications— and —given together in cycles can work better than the current standard treatment for newly diagnosed glioblastoma, a serious type of brain cancer. You would take this medication combination after you've already completed the standard six weeks of radiation and chemotherapy. The goal is to see if this approach can help people live longer and delay the cancer from coming back.
Glioblastoma is a very aggressive brain cancer with a poor outlook—most people survive only about 14–15 months with current treatment. Doctors need better options to improve survival and quality of life, and this trial is testing whether combining these two medications could be that improvement.
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You would take (an oral chemotherapy pill) twice daily for 14 days, then add (another oral chemotherapy) twice daily for days 10–14, followed by a 14-day break—and this cycle repeats. The trial will monitor you with regular blood tests and clinic visits to check how well the treatment is working and whether you're experiencing any side effects. Your participation would continue for at least six months, and possibly longer depending on how your cancer responds.
AI-generated summary from trial data · Jul 21, 2026 · Not medical advice
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