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Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination approach for people with Crohn's disease that hasn't responded to standard medications. You would receive a stem cell transplant (using your own cells) followed by ongoing treatment with , a medication that helps reduce inflammation in the digestive tract. The goal is to see if this approach can help control symptoms and reduce flare-ups in people for whom other treatments have failed.
Most current Crohn's disease medications only work for about half of patients, and many people who initially improve eventually relapse and need new options. This trial exists because doctors need better treatments for people whose disease doesn't respond to the strongest available medications.
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You would undergo a stem cell collection procedure where doctors harvest stem cells from your blood, followed by chemotherapy to prepare your body, then a transplant of your own stem cells back into your body. After recovery, you would receive ongoing maintenance treatment with through infusions or injections. You would have regular clinic visits, blood tests, and follow-up endoscopy procedures to monitor how well the treatment is working and check for side effects. The trial enrolls about 50 people total.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States