Plain-English translation of NCT03223922 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a specialized type of whole brain radiation therapy designed to treat cancer that has spread to your brain. The key difference is that this approach carefully avoids delivering radiation to a specific part of your brain called the corpus callosum genu — an area that plays an important role in memory, attention, and thinking skills. The goal is to treat your brain tumors effectively while protecting your cognitive abilities.
Whole brain radiation therapy is an effective cancer treatment, but it can cause cognitive problems like memory loss, trouble concentrating, and changes in mood. Researchers believe that by protecting particularly sensitive brain structures from radiation damage, they may be able to preserve your thinking and memory abilities while still effectively treating the cancer.
You likely qualify if…
You likely don't qualify if…
You would receive whole brain radiation therapy delivered over multiple sessions, with the radiation beam carefully shaped to avoid the corpus callosum genu area. Throughout the study, you would complete regular thinking and memory tests and brain imaging scans to see if this approach helps preserve your cognitive abilities. You would also be asked about your mood, motivation, and overall quality of life as part of follow-up visits.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States
Sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Enrollment target
~24 participants
Started
July 2017
Primary completion
December 2026
Age range
18 Years – 100 Years
Last updated on clinicaltrials.gov in July 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Kristin Redmond, MD
The SKCCC at Johns Hopkins
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.