Plain-English translation of NCT03228732 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Type 1 Diabetes Mellitus research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
When you have type 1 diabetes, your body sometimes struggles to notice and respond to low blood sugar, which can be dangerous. This study tests whether (an antidepressant) and a natural hormone called —either alone or together—can help your body better defend itself when blood sugar drops too low. Researchers will measure how well your body responds to low blood sugar while taking the medication, a hormone supplement, both, or a placebo.
People with type 1 diabetes often lose the ability to feel warning signs of dangerous low blood sugar, which puts them at risk. This trial is exploring whether common, available medications might help restore your body's natural protective responses.
You likely qualify if…
You likely don't qualify if…
You will visit the research center twice, about 8 weeks apart. At each visit, you'll spend two days undergoing controlled tests where researchers carefully monitor your blood sugar and measure how your body responds—first to normal blood sugar, then to low blood sugar. Between visits, you'll take either the medication, the hormone supplement, both, or a placebo daily for 8 weeks. Blood samples and body measurements will be taken to track your responses.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
United States