Stem cell transplant with a half-matched family donor for sickle cell disease

This trial is testing a stem cell transplant approach for people with severe sickle cell disease. You would receive special medications before the transplant to prepare your body, then receive stem cells from a family member who is a half-match for your immune system genes. The goal is to replace your damaged blood-forming cells with healthy ones and potentially cure your sickle cell disease.

Many people with sickle cell disease have severe complications like strokes, repeated pain crises, and organ damage that aren't fully controlled by current medications. This treatment aims to offer a potential cure by using a stem cell transplant from family members who don't need to be a perfect genetic match, which could help more patients access this life-changing therapy.