Plain-English translation of NCT03280511 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a procedure called pressurized intraperitoneal aerosol chemotherapy () using oxaliplatin, a chemotherapy drug delivered directly into your abdomen as a fine mist during a minimally invasive laparoscopic surgery. The goal is to help prevent colon cancer from spreading to the lining of the abdomen (a common place where colon cancer can return) in patients at high risk of recurrence who have already had their cancer surgically removed.
Even after surgery and standard chemotherapy, colon cancer comes back in about 1 in 4 patients, and the abdominal lining is a common site where it returns. This medication is being tested as a preventive treatment to try to catch and eliminate any invisible cancer cells that might be hiding in the abdomen before they develop into noticeable tumors.
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You would have two minimally invasive laparoscopic procedures (about 5 weeks apart), starting about 2 months after your colon surgery. During each procedure, the doctor will rinse your abdomen, take small tissue samples, and deliver the chemotherapy medication as a pressurized aerosol into your abdomen. You would then have follow-up CT scans at 12, 24, and 36 months to monitor for any signs of cancer recurrence.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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