Plain-English translation of NCT03295773 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is tracking how fatty plaques in brain arteries change over time in people who have had a stroke. Researchers will use a special 3D imaging technique called rotational angiography to take detailed pictures of the arteries at the start and again one year later. The goal is to understand how these plaques evolve and what factors—like blood pressure control, cholesterol levels, and blood sugar—affect whether they get better, stay the same, or get worse.
Doctors know that fatty buildup in brain arteries causes strokes, but they don't fully understand how these plaques change over time or what treatments work best to slow or stop their growth. This study could help doctors predict which patients are at highest risk and improve how they manage stroke prevention.
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You will receive dual blood-thinning medications for the first 4 weeks, then aspirin alone. You'll have a special 3D imaging scan of your brain arteries at the beginning and again 12 months later to see how your plaques have changed. Throughout the year, you'll have regular check-ins with your doctor to manage your blood pressure, cholesterol, blood sugar, and smoking status according to specific targets. The doctors will then compare your imaging results with how well your risk factors were controlled to understand what helps slow plaque growth.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
Hong Kong
Sponsor
Chinese University of Hong Kong
Enrollment target
~140 participants
Started
August 2016
Primary completion
December 2026
Age range
18 Years – 80 Years
Last updated on clinicaltrials.gov in February 2026.
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Central contact
Thomas Wai Hong LEUNG, FRCP
Chinese University of Hong Kong
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