Plain-English translation of NCT03303586 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Asthma research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Many people with asthma experience worsening symptoms at night—including shortness of breath, chest tightness, coughing, and wheezing. This trial is testing whether wearing affordable, over-the-counter compression stockings (tight stockings that improve blood flow in the legs) during the day might help reduce these nighttime symptoms by preventing fluid from shifting out of the legs and into the chest while you sleep.
About two-thirds of people with asthma have nighttime symptoms, and current treatments don't fully solve the problem for everyone. Early research suggests that when you lie down to sleep, fluid from your legs can shift into your chest and narrow your airways. This trial is exploring whether compression stockings worn during the day could prevent this fluid shift and improve your sleep and breathing at night.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to either wear compression stockings or not wear them for two weeks, then switch to the other group for another two weeks. When wearing the stockings, you'll put them on each morning when you wake up and remove them just before bed. You'll keep a simple diary to record when you put them on and take them off, and the research team will call you after one week to make sure they fit properly. The entire study lasts about four weeks.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Canada
Sponsor
University Health Network, Toronto
Enrollment target
~40 participants
Started
February 2017
Primary completion
August 2026
Age range
20 Years – 75 Years
Last updated on clinicaltrials.gov in March 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Cristina O Francisco
Scientist
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.