Plain-English translation of NCT03314974 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a stem cell transplant procedure for people with serious blood cancers or bone marrow diseases. You would receive high-dose chemotherapy or radiation to prepare your body, then receive healthy stem cells from a donor (either a family member or an unmatched donor). After the transplant, you'll receive medications including post-transplant cyclophosphamide, tacrolimus, and mycophenolate mofetil to help your new immune system work properly and prevent complications.
Many blood cancers and bone marrow diseases are difficult to cure with chemotherapy alone. This trial is testing whether stem cell transplants, combined with a specific approach to preventing rejection and complications, can improve survival and quality of life for patients with these serious conditions.
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You would first complete testing to confirm your organs are healthy enough for transplant. You would then receive intensive chemotherapy or radiation therapy to prepare your body for the new stem cells. Next, you would receive the donor stem cells through an infusion. Following the transplant, you would receive the preventive medications for several months and have frequent follow-up appointments to monitor your recovery, watch for complications, and check that the transplant is working.
AI-generated summary from trial data · Jul 15, 2026 · Not medical advice
United States