Plain-English translation of NCT03320304 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is testing VNS Therapy®, a device that is surgically implanted to stimulate the vagus nerve in your neck as a way to help treat depression that hasn't responded well to standard antidepressant medications or therapy. Researchers want to understand how well this treatment works for people with chronic or recurring depression in real-world medical settings. You would be followed for up to 5 years after implant to see how the treatment affects your depression over time.
Many people with depression don't get better with medications or standard therapy alone, and doctors need better treatment options for these patients. This medication offers a different approach that may help when traditional treatments haven't worked.
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If you enroll, you'll have a baseline visit 1–6 weeks before surgery to implant the vagus nerve stimulation device. After the implant procedure, you'll visit the clinic regularly for at least 3 years (and up to 5 years) so doctors can monitor how you're doing and check that the device is working well. During these visits, you'll complete questionnaires about your mood and depression symptoms to help researchers understand the treatment's effectiveness.
AI-generated summary from trial data · Jul 8, 2026 · Not medical advice
Austria
Belgium
Germany