Plain-English translation of NCT03323216 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Heart Failure research guide →The BIO-2-HEART study is looking for hidden clues in your blood that could help doctors predict whether a heart device called a cardiac resynchronization therapy (CRT) device will work well for you. Researchers will collect blood samples from patients with and without type 2 diabetes who are having this device implanted to better understand how diabetes affects the heart and which patients are most likely to improve with this treatment.
Not all patients benefit equally from CRT device implants, even when they meet all the standard selection criteria. This study aims to identify biological markers in the blood that could predict ahead of time which patients will respond well to the treatment, so doctors can make better decisions about who should receive the device.
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Before your scheduled heart device implant or heart procedure, you'll complete a brief questionnaire and a 6-minute walking test. During the procedure itself, doctors will place small tubes in an artery and veins to monitor your blood pressure and collect blood samples from different locations—your heart's blood vessels, your artery, and your peripheral veins. The entire process happens during your clinically necessary procedure, which an experienced cardiac team will perform.
AI-generated summary from trial data · Jul 13, 2026 · Not medical advice
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