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Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a specialized MRI imaging technique called MR spectroscopy to monitor how brain tumors respond to radiation treatment. Researchers want to see if this new scan can better track changes in tumor metabolism before and after radiation therapy, and whether it works differently in healthy people, people with memory problems, and cancer patients.
Currently, doctors have limited tools to quickly tell whether brain cancer is responding to radiation therapy. This new imaging technique might provide earlier and more detailed information about how tumors are changing, which could help doctors adjust treatment plans faster and improve outcomes.
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If you are a healthy volunteer or have memory concerns, you will come in for a single MRI visit lasting about 60–75 minutes, during which you will receive an injection of the special contrast agent and have scans performed. If you have brain cancer being treated with radiation, you will have MRI scans before your radiation therapy begins, and then again 1–5 days after treatment ends—and possibly additional scans later if imaging shows certain changes. All scans take place at Sunnybrook Health Sciences Centre.
AI-generated summary from trial data · Jul 21, 2026 · Not medical advice
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