Plain-English translation of NCT03343873 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how three sedation medications—, , and —affect how different parts of your brain communicate with each other. You would receive one of these medications while lying in an MRI scanner, which takes pictures of your brain activity at different levels of sedation. This helps doctors learn which medication might be safest and best for future patients.
Sedation medications are used every day in hospitals and surgery centers, but doctors don't fully understand how each one affects the brain's networks. By studying this, researchers hope to improve anesthesia safety and choose the right medication for different patients and situations.
You would visit the hospital for a study session where you receive one of the three sedation medications through an IV. While the medication takes effect, you lie in an MRI scanner that takes pictures of your brain activity—first while you're awake, then as the medication deepens your sedation to different levels, and finally as you wake up. The research team monitors your heart rate, breathing, and oxygen levels throughout. The entire session typically takes a few hours.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
China
Enrollment target
~240 participants
Started
April 2017
Primary completion
December 2025
Age range
18 Years – 65 Years
Sex
Male only
Last updated on clinicaltrials.gov in August 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Ruquan Han, M.D., Ph.D
Department of Anesthesiology, Beijing Tiantan Hospital