Plain-English translation of NCT03374215 on ClinicalTrials.gov ↗ · Source last updated ·
This study is looking for genetic causes of primary aldosteronism — a common type of high blood pressure that affects about 1 in 30 to 50 adults and is often harder to treat with standard medications. The researchers want to understand why this condition appears to damage the heart, kidneys, and blood vessels more severely in Black adults compared to other groups, and they're searching for specific genetic mutations that might explain these differences.
Primary aldosteronism is responsible for 6–25% of resistant high blood pressure cases, but very little is known about the genetic causes in Black populations. Understanding these genetic differences could help doctors better diagnose and treat this condition in communities most affected by it.
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If you enroll as a main participant, you will visit the NIH for evaluation and testing to confirm your diagnosis, which may include blood tests and imaging scans of your adrenal glands. Family members age 7 and older may participate by providing a blood sample for genetic testing. The study aims to enroll about 1,150 people total, and researchers will follow participants over time to understand how their condition develops.
AI-generated summary from trial data · Jul 20, 2026 · Not medical advice
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