Plain-English translation of NCT03401047 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers want to understand why women with polycystic ovary syndrome (PCOS) have trouble with ovulation. This study will give women —a natural hormone—through skin patches to see how their bodies respond compared to women without PCOS. By measuring hormone levels in blood and urine daily, the researchers hope to learn more about what makes PCOS different.
Women with PCOS often have irregular periods and difficulty getting pregnant because their bodies don't respond normally to hormonal signals that trigger ovulation. Understanding exactly how this happens could lead to better treatments in the future.
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You will visit a clinical research unit daily for about 9 days during a specific part of your menstrual cycle. Each day, study staff will place a new patch on your skin and take a small blood sample. You will also collect all your urine in 12-hour batches throughout the study. On one day, you'll have an ultrasound to check your ovaries. The entire study takes about 1–2 weeks from start to finish.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
University of Virginia
Enrollment target
~37 participants
Started
November 2017
Primary completion
October 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 30 Years
Sex
Female only
Last updated on clinicaltrials.gov in August 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Melissa G Gilrain, B.S.
University of Virginia
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.