Plain-English translation of NCT03402139 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is trying to understand why babies born smaller than expected (called intrauterine growth restriction) have a higher risk of becoming obese and developing metabolic diseases later in life. Researchers will compare blood samples from small babies and normally-sized babies to look at changes in their genes and immune cells that might explain this increased obesity risk.
We know from large population studies that babies born smaller than expected face higher risks of obesity, heart disease, and diabetes as adults, but we don't fully understand why this happens. This study is trying to discover the biological mechanisms — specifically changes in how genes are turned on and off — that might explain this connection.
If you join this study, you and your newborn will have blood samples collected after delivery — one sample from the baby's umbilical cord blood and possibly another sample from the baby later. There are no medications, treatments, or lifestyle changes required. Researchers will follow your child's growth and weight over time to see how the genetic changes they find in the blood samples relate to obesity risk as your child grows.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Sponsor
Montefiore Medical Center
Collaborators
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Icahn School of Medicine at Mount Sinai
Enrollment target
~163 participants
Started
September 2018
Primary completion
December 2021
Age range
1 Hour – 24 Months
Last updated on clinicaltrials.gov in August 2026.