High-dose vitamin C added to chemotherapy for blood cancers

This trial is testing whether ascorbic acid (high-dose vitamin C given through an IV) can improve how well chemotherapy works for people with lymphomas and other blood cancers that have come back or stopped responding to their last treatment. Some participants will receive the medication along with chemotherapy, while others will receive chemotherapy with a placebo (salt water) to compare results. The goal is to see if adding this medication helps more patients respond to treatment.

Many people with lymphomas and blood cancers either have their disease return after treatment or find that their cancer stops responding to chemotherapy. Doctors are looking for ways to make existing chemotherapy treatments more effective, and this trial tests whether this medication might be that missing piece.