Plain-English translation of NCT03422731 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This research study is designed to track changes in your bone marrow during treatment for acute myeloid leukemia or acute lymphoblastic leukemia. Researchers will use advanced imaging scans—like CT and MRI—along with bone marrow samples to understand how your bone marrow responds to different types of radiation and chemotherapy treatments. The goal is to better predict how well the treatment is working and to improve care for future patients.
Currently, doctors have limited ways to see exactly what's happening inside the bone marrow during leukemia treatment. This trial aims to develop better imaging methods that can show doctors early on whether treatment is working, which could help them adjust care more quickly if needed.
Depending on which group you're assigned to, you will have imaging scans (CT and MRI) and bone marrow biopsies at several time points—at the start of treatment, at day 30, at day 100, and at one year. Some participants may also have a special PET scan that takes about 2 hours. You'll be followed for at least one year, with the possibility of additional scans if your leukemia returns. The study is observational, meaning researchers are watching and measuring rather than testing a new drug.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States