Testing a new medication to improve chronic sinus infection treatment

This is a small research study testing whether a medication called ivacaftor can help treat chronic sinus infections that haven't responded well to standard treatments. Ivacaftor works by helping your body's natural defenses clear thick mucus from your sinuses. Half of the participants will receive standard sinus care plus this medication, while the other half will receive standard care alone.

Chronic sinus infections are a major problem affecting millions of people and causing real suffering. Current treatments — antibiotics and steroids — don't work well for everyone, especially when bacteria become resistant to antibiotics. Researchers believe this medication might help by fixing how your sinuses produce and clear mucus, addressing the root cause rather than just treating symptoms.